This SIBO Support Box contains 4 primary ingredients pre-portioned in easy-to-use AM and PM packets (best taken with food).  I chose these products for several reasons; here is a brief explanation. The first ingredient in each packet is Atrantil Atrantil is the only patented polyphenol blend in the world that has been shown in clinical trials to help 4 out of 5 people address their symptoms of bloating, abdominal pain, and change in bowel habits. Atrantil is composed of three powerful natural polyphenols, that help get rid of the gas and the problematic bacteria in the small intestine. When your microbiome uses the Atrantil as fuel, it produces beneficial molecules that have potent anti-cancer, anti-aging, and anti-inflammatory benefits throughout your entire body. The second ingredient in each packet is Diamine Oxidase (DAO) Diamine Oxidase is an enzyme produced by the lining of your digestive tract to help control the amount of histamine that gets absorbed in your body. Diamine Oxidase is also known as DAO for short. Histamine is a compound that is involved in digestion and supports the nervous system and the immune system. When histamine levels get too high It can disrupt all three of these systems. The DAO produced in your small intestine is there to neutralize the histamine that is both in foods and histamine produced by SIBO bacteria. Anytime you eat anything with more histamine than your body can neutralize, it will get absorbed into your body leading to excess histamine. When this excess histamine is absorbed, it can cause issues like abdominal pain, cramps, diarrhea, constipation, and can also cause brain fog, fatigue, anxiety, and even migraines. Some of the more common foods that have a high histamine are avocados, spinach, fermented foods, cheese, alcohol, and smoked meats just to name a few. There are many medications which decrease DAO: aspirin, ibuprofen, blood pressure medications, and anti-depressants. When you combine Atrantil with a high-quality DAO, like the one we are using, it makes a huge difference in what you can eat, and significantly reduces the effects of too much histamine. The third ingredient in each packet is IgY Immunoglobulin Immunoglobulin is known as an antibody. The most commonly known among the SIBO community is bovine IgG.  I use IgY because it is more effective than IgG. Due to its shape, IgY can resist the digestive process and remain intact in the gut to get rid of bacteria, viruses, and allergens. If you have SIBO you may experience “leaky gut”, where small bacterial particles and allergens leak through the tight junctions in the gut and ignite the immune response resulting in inflammation. These small bacterial particles are called lipopolysaccharides or LPS. LPS is now considered one of the major causes of dementia and autoimmune disease. IgY is known to tightly bind to LPS and remove it from the small bowel so that it can’t leak through the tight junctions and cause inflammation. Inflammation always indicates that the body is in distress. Think of IgY like a bulldozer that removes SIBO debris: LPS, bacterial pieces, viruses, and food allergens. It moves that debris down into the colon where it then passes out of your body. The final ingredient is included only in the PM packet: Ashwagandha I put ashwagandha in the SIBO Support Box because we know that there is a significant brain gut connection, and Ashwagandha helps improve that connection and ensure you have proper sleep. Ashwagandha has been shown to improve anxiety, decrease cortisol and help improve the quality of sleep in those with and without insomnia. This is extremely important because if you have anxiety, it can cause intestinal motility issues which results in persistent SIBO and more inflammation. Conclusion: KBMD Health makes no medical claims.  Science and Clinical Application support the conclusion that these high-quality ingredients, when used in conjunction with each other, will address your SIBO symptoms and should help your body reduce inflammation, and sleep better, resulting in relief.